Klinisk prövning på Idiopathic Membranous Nephropathy: 100 mg

SynAct Pharma - Redeye

"We have during the summer had very good progress in the recruitment to the study, which means that we now have completed recruitment in part 1 of the study. A double blind trial in two parts in people with active newly discovered rheumatoid arthritis. The experiment takes place in several hospitals. In order to better assess the mechanism of action of the active study drug AP1189, AP1189 is compared to an inactive substance (placebo). In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inhibitor or Angiotensin-2 receptor antagonists in a once-daily dos SynAct Pharma AB ('SynAct Pharma') today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company's lead candidate drug AP1189 in adults diagnosed wi Om AP1189 Verkningsmekanismen för SynAct Pharmas ledande läkemedelskandidat AP1189 är att främja resolution av inflammation genom melanokortinreceptor-aktivering direkt på makrofagerna, vilket minskar den proinflammatoriska aktiviteten hos makrofager, och genom att stimulera så kallad makrofagefferocytos har den en specifik förmåga att rensa inflammatoriska celler (J Immun 2015, 194 En konkret utvecklingsplan stärker förhandlingspositionen i framtida diskussioner och utgör en viktig del av Synact Pharmas affärsutvecklingsstrategi för AP1189. Intresset för läkemedelskandidaten har samtidigt varit stort bland investerare, vilket reflekteras i det faktum att den riktade nyemissionen blev kraftigt övertecknad. Det säger vd Jeppe Øvlesen och forskningschef Thomas Möjligheten för AP1189 att bli en ny behandlingsmetod inom resolutionsterapi bedömer vi som lovande och med vår pågående studie inom RA beräknar vi kunna erhålla Proof-of-Concept för AP1189 under Q1 2021 samt rapportera interimsresultat i slutet av det första kvartalet 2020.

2020 — initiation of a Phase II clinical study to evaluate the safety and efficacy of the company's lead candidate drug AP1189 in adults diagnosed wi SynAct Pharma AB ("SynAct") today announced that dosing in the second part of the exploratory clinical Phase 2 study with AP1189 in Covid-19 patients Press releases · March 18, 2021SynAct has initiated dosing in part 2 of the clinical Phase II study with AP1189 in Covid-19 infected patients UK version · March 18, 18 mars 2021 — SynAct Pharma AB ("SynAct") today announced that dosing in the second part of the exploratory clinical Phase 2 study with AP1189 in This study is an exploratory, randomized, double-blind, multicenter, placebo-controlled study with repeated doses of AP1189. The study population will consist of SynAct has initiated dosing in part 2 of the clinical Phase II study with AP1189 in Covid-19 infected patients UK version. SynAct Pharma AB ("SynAct") today SynAct has initiated dosing in part 2 of the clinical Phase II study with AP1189 in Covid-19 infected patients UK version. SynAct Pharma AB ("SynAct") today 2 dec. 2019 — Recently initiated phase II study in active joint disease: SynAct's first phase II clinical trial with the leading compound AP1189 for treatment of 9 nov. 2020 — Based on the interim analysis, the DSMB recommend continuing into part 2 of the BEGIN study with AP1189 dosed at either 50 mg, or 100 mg 18 mars 2021 — explorativa kliniska fas 2-studien med AP1189 på Covid-19-patienter och professor Mauro Perretti, PhD, William Heavy Research Institute, 07:04 SynAct Pharma AB (SynAct) today announced that dosing in the second part of the exploratory clinical Phase 2 study with AP1189 in Covid-19 patients 2 apr. 2020 — Även om Covid-19 har skapat ett nytt indikationsutrymme för AP1189, to start a study very soon« — Jeppe Øvlesen, CEO SynAct Pharma.

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In the study, AP1189 will be examined as a potentially additional therapy for patients with idiopathic membranous nephropathy who have nephrotic syndrome. A Study of the Safety, Tolerability and Efficacy of Treatment With AP1189 in Early RA Patients With Active Joint Disease (SynAct-CS002) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

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2020 — Mauro Perretti, doktorand vid William Institute for Heavy Research, Barts and London School of Medicine, Queen Mary University, London, Free essays, homework help, flashcards, research papers, book reports, term AP1189 - en ny behandling för psoriasisartrit och andra inflammatoriska Joe Bidens team förväntar sig att Donald Trump kommer att leverera mängder av lögner under den första debatten presidentkandidaterna emellan, som går av 14 feb. 2021 — Gör din egen research innan du investerar. V2nischen sammanfattar vilken otrolig marknadspotential #SynActs substans AP1189 har. 5 apr.

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• Preparatory activities to initiate phase II study with AP1189 within NS. The Company • Continue the business development in SynAct with out-licensing and partnership dialogues.

The patients will be enrolled at medical centers in Brazil and in a collaboration between SynAct Pharma, Queen Mary A multicenter, two-part, randomized, double-blind, placebo-kontrolled, 4-week study with repeated doses of AP1189. The study population will consist of newly diagnosed subjects with severe active Rheumatoid Arthritis, defined with a Clinical Disease Activity score (CDAI) > 22, who are to start up-titration with methotrexate. The second part of the study is set up to evaluate the safety and efficacy of a two-weeks dosing regimen with AP1189 vs placebo as add on therapy in patients with Covid-19 induced pulmonary insufficiency, defined as a need for supplementary oxygen to maintain normal saturation. This study is an exploratory, randomized, double-blind, multicenter, placebo-controlled study with repeated doses of AP1189.
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SynAct Pharma Initiates Phase II Study with AP1189 for the

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SynAct Pharma Initiates Phase II Study with AP1189 for the Treatment of ARDS in COVID-19 Patients Wed, Sep 23, 2020 08:28 CET. SynAct Pharma AB ("SynAct Pharma") today announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress 2020-07-15 SynAct Pharma has announced the initiation of a Phase II clinical study to evaluate the safety and efficacy of the company’s lead candidate drug AP1189 in adults diagnosed with COVID-19 and with early signs of Acute Respiratory Distress Syndrome (ARDS). SynAct Pharma AB ("SynAct") today announced that the company has initiated a Phase II clinical study with the AP1189 compound in idiopathic membranous nephropathy patients with Nephrotic Syndrome.. In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inhibitor or Angiotensin-2 receptor antagonists in a once-daily dose 2020-09-03 In the Phase IIa study, AP1189 will be tested in a double-blind, placebo-controlled multicentre study as add-on therapy to ACE-inh ibitor or A ngiotensin-2 receptor antagonists in a once-daily dose regimen for four weeks with the primary purpose to show treatment effect on urinary protein excretion relative to pre-treatment levels and placebo.